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KMID : 0351619700110020401
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Kyungpook Medical Journal
1970 Volume.11 No. 2 p.401 ~ p.406
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Effects of Diphenylhydantoin on Isolated Atrium of the Rabbit
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Abstract
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Effects of diphenylhydantoin and diphenylhydantoin with dichloroisoproterenol, propranolol, histamine or epinephrine in isolated atrium of rabbit were studied respectively.
Atrium of rabbit weighing about 2kg body weight were isolated. Contraction of spontaneously beating atrium in 29℃ of oxygenated Ringer-Locke solution were recorded on Kymograph and above drugs were added in these solution respectively.
The results obtained in this study were as follows:
1. In 2×10^(-5)gm/ml of diphenylhydantoin and 5×10^(-5)gm/ml of propranolol, the amplitude and the rate of contraction of atrium were inhibited, and inhibitory effects of both drugs on the atrium were additive.
2. Diphenylhydantoin inhibit the positive inotropic effect of dichloroisoproterenol and in their high concention, the inhibitory effects of both drugs were additive.
3. Histamine and epinephrine antagonized the inhibitory effect of diphenylhydantoin.
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KEYWORD
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